New Horizons 2020

December 05, 2019

Congratulations to Martina and Susan for the presentations at UCC New Horizons School of Medicine research day 2020. Martina IRC-funded abstract won best poster prize for her work on the study of the function and therapeutic potential of histone deacetylase inhibition in Parkinson's disease. Susans RISM-funded abstract was selected for a talk on her work on the development of neurotrophic factor therapy in alpha-synuclein models of Parkinson's. Very well done to you both!!

New study in Oxidative Medicine and Cellular Longevity

December 03, 2019

Congratulations to Amnah on the publication of our new study in Oxidative Medicine and Cellular Longevity.  Neuroblastoma is responsible for 15% of childhood deaths from cancer. Aggressive tumors have a high mortality rate linked to chemoresistance. In this study we show that a dietary chalcone molecule called 4HC can kill MYCN-amplified neuroblastoma cells through oxidative-stress induced mitochondrial dysfunction. This established 4HC as new therapeutic molecule to induced the death of chemoresistance neuroblastoma cells.

UCC Research Supervisor of the Year

November 05, 2019

Congratulations to Ger O'Keeffe on the award of UCC Research Supervisor of the Year 2019. The UCC Research Awards Programme has been established to recognise the extensive contributions made by UCC researchers across all fields.  They recognise and celebrate those UCC researchers who are making exceptional and influential research contributions, pushing boundaries, enhancing knowledge, and raising the national and international research profile of the University. 

New study on C-Section and Child Cognitive Development

October 21, 2019

Congratulations to Michael on the publication of our new study in Social Psychiatry and Psychiatry Epidemiology in collaboration with Dr. Ali Khashan in the School of Public Health. Global rates of caesarean section (CS) rates have increased rapidly in recent years. This is a growing public health concern as CS may impact cognitive outcomes in childhood. However, the evidence for this association is limited and inconsistent. Here we investigated the relationship between obstetric mode of delivery and longitudinal cognitive outcomes in childhood in the UK Millennium Cohort.

Thesis submissions!

September 14, 2019

It has been a busy period of thesis writing and congratulations to Gareth, Adam, Alex, Kelsey and Sarah on submission of their MSc theses. Gareth, Adam, Alex and Sarah work on examining and characterising the molecular changes induced in vitro and in vivo in models of Parkinson's disease, that regulate the survival and neurite growth of midbrain dopaminergic neurons. In our developmental work, Kelsey worked on characterising the expression and function of histone deacetylases in MYCN-amplified neuroblastoma. Well done to all.

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All of the team are fully committed to scientific communication and we welcome enquires from patients or the general public about our work. In this section you can find news and updates on our on-going work as it happens and lay project summaries highlighting what our work is about, the goals of our research and the implications and benefits of these research findings. All of the entries are written by a member of the team. Please contact us if you would like further information. 

O'Keeffe lab, University,

College Cork, Cork, Ireland

© 2018 O'Keeffe lab

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