JOURNAL COVERS & NEUROART

PUBLICATIONS

A complete list of publications can also be found on the ORCID website.

2020

Association between Preeclampsia and Attention Deficit Hyperactivity Disorder: A Population-Based and Sibling-Matched Cohort Study.

Maher GM, Dalman C, O'Keeffe GW, Kearney PM, McCarthy FP, Kenny LC, Khashan AS.

Acta Psychiatr Scand. 2020 Feb 13. doi: 10.1111/acps.13162. [Epub ahead of print]

PMID: 32056200

The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease.

Goulding SR, Sullivan AM, O'Keeffe GW, Collins LM.

Neural Regen Res. 2020 Aug;15(8):1432-1436. doi: 10.4103/1673-5374.274327.

PMID: 31997802

Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons.

Furlong RM, O'Keeffe GW, O'Neill C, Sullivan AM.

Neurosci Lett. 2020 Feb 16;720:134777. doi: 10.1016/j.neulet.2020.134777. Epub 2020 Jan 21.

PMID: 31978495

Association between preeclampsia and autism spectrum disorder: a population-based study.

Maher GM, O'Keeffe GW, Dalman C, Kearney PM, McCarthy FP, Kenny LC, Khashan AS.

J Child Psychol Psychiatry. 2020 Feb;61(2):131-139. doi: 10.1111/jcpp.13127. Epub 2019 Sep 17.

PMID: 31531876

The association between caesarean section and cognitive ability in childhood.

Hanrahan M, McCarthy FP, O'Keeffe GW, Khashan AS.

Soc Psychiatry Psychiatr Epidemiol. 2019 Oct 22. doi: 10.1007/s00127-019-01798-4. [Epub ahead of print]

PMID: 31641827

2019

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells.

Alshangiti AM, Tuboly E, Hegarty SV, McCarthy CM, Sullivan AM, O'Keeffe GW.

Oxid Med Cell Longev. 2019 Dec 5;2019:1670759. doi: 10.1155/2019/1670759. eCollection 2019.

PMID: 31885773

A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role? 

Maher GM, McCarthy FP, McCarthy CM, Kenny LC, Kearney PM, Khashan AS, O’Keeffe GW. 

Int. J. Dev. Neurosci. 2019 Oct;77:69-76.  doi: 10.1016/j.ijdevneu.2018.10.00

PMID: 30391740

Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling.

Mazzocchi M, Wyatt SL, Mercatelli D, Morari M, Morales-Prieto N, Collins LM, Sullivan AM, O'Keeffe GW.

Front Cell Dev Biol. 2019 Sep 13;7:191. doi: 10.3389/fcell.2019.00191. eCollection 2019.

PMID: 31572723

Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis.

Manzari N, Matvienko-Sikar K, Baldoni F, O'Keeffe GW*, Khashan AS*.

Soc Psychiatry Psychiatr Epidemiol. 2019 Nov;54(11):1299-1309. doi: 10.1007/s00127-019-01745-3. Epub 2019 Jul 20.

PMID:31324962

Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T alpha-synuclein

Goulding S, Sullivan AM, O'Keeffe GW*, Collins LM*.

Park Rel. Dis. 2019 Jul;64:194-201.  doi: 10.1016/j.parkreldis.2019.04.008.

PMID: 31000327

Utilizing the scholarship of teaching and learning to design and anatomy pedagogy course.

Balta J, O'Keeffe GW, Supple B.

Eur. J. Anat. 2019 May; 23(3): 233-240.  http://www.eurjanat.com/data/pdf/eja.190131jb.pdf

PMID: in progress

The Effect of Hypertensive Disorders of Pregnancy on the Risk of ADHD in the Offspring.

Böhm S, Curran EA, Kenny LC, O'Keeffe GW, Murray D, Khashan AS.

J Atten Disord. 2019 May;23(7):692-701. doi: 10.1177/1087054717690230. 

PMID: 28162026

Radiologists views on the anatomical knowledge of junior doctors and on the teaching of anatomy in medical curricula.

O'Keeffe GW, Davy S, Barry DS.

Ann. Anat. 2019 May;223:70-76. doi: 10.1016/j.aanat.2019.01.011. Epub 2019 Feb 4.

PMID: 30731200

Prenatal maternal stress and the risk of neurodevelopmental disorders in the offspring: A systematic review and metanalysis protocol.

Manzari N., Matvienko-Sikar K, Baldoni F, O'Keeffe GW#, Khashan AS#.

HRB Open Research. HRB Open Res 2019, 1:15 doi: 10.12688/hrbopenres.12827.2

https://doi.org/10.12688/hrbopenres.12827.2

The distribution of the proteoglycan FORSE-1 in the developing mouse central nervous system.

Kelly A, O'Malley A, Redha M, O'Keeffe GW, Barry DS.

J. Anat. 2019 Feb;234(2):216-226. doi: 10.1111/joa.12907.

PMID: 30474148

The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells.

Alshangiti A, Togher KT, Hegarty SV, Sullivan AM, O'Keeffe GW.

Neuronal Signalling 2019, Jan 30, 3 (1) NS20180201; doi: 10.1042/NS20180201

PMID: in progress

2018

Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease.

O'Keeffe GW, Sullivan AM.

Park Rel Dis. 2018 Nov;56:9-15. doi: 10.1016/j.parkreldis.2018.06.025.    

PMID: 29934196 

Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants.

Togher KL, O'Keeffe GW, Khashan AS, Clarke G, Kenny LC.

Sci Rep. 2018 Oct 11;8(1):15151. doi: 10.1038/s41598-018-33357-3.    

PMID: 30310158

 

Association of hypertensive disorders of pregnancy with risk of neurodevelopmental disorders in offspring.

Maher GM, O'Keeffe GW, Kearney PM, Kenny LC, Dinan TG, Matteson M, Khashan AS.

JAMA Psychiatry. 2018 Aug 1;75(8):809-819. doi: 10.1001/jamapsychiatry.2018.0854.

PMID: 29874359

Exposure to hypertensive disorders of pregnancy increases the risk of autism spectrum disorder in affected offspring.

Curran EA#, O'Keeffe GW# Looney AM, Moloney G, Hegarty SV, Murray DM, Khashan AS, Kenny LC. 

Mol. Neurobiol. 2018 Jul;55(7):5557-5564. doi: 10.1007/s12035-017-0794-x.    

PMID: 28975539

Mild prenatal hypoxia-ischemia leads to social deficits and central and peripheral inflammation in exposed offspring.

O'Driscoll DJ, Felice VD, Kenny LC, Boylan GB, O'Keeffe GW.

Brain Behav Immun. 2018 Mar;69:418-427. doi: 10.1016/j.bbi.2018.01.001.

PMID: 29355822

Inhibition of microRNA-181a promotes midbrain neuronal growth through a Smad1/5 dependent mechanism: implications for Parkinson’s disease.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Neuronal Signaling 2018 Jan 1; 2(1) NS20170181; doi: 10.1042/NS20170181

PMID: in press

2017

Targeting transcriptional regulators to regeneration midbrain dopaminergic axons in Parkinson's disease.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Neural Regen Res. 2017 Nov;12(11):1814-1815. 

PMID: 29239326

Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol.

Maher GM, O'Keeffe GW, Kenny LC, Kearney PM, Dinan TG, Khashan AS.

BMJ Open. 2017 Oct 5;7(10):e018313. doi: 10.1136/bmjopen-2017-018313.

PMID: 28982838

A case study in the use of primary literature in the context of authentic learning pedagogy in the undergraduate neuroscience classroom.

O'Keeffe GW, McCarthy MM.

J Undergrad Neurosci Educ. 2017 Fall;16(1):A14-A22.

PMID: 29371836

An attitudinal survey of neuroscience students regarding theirs views on the relevance of lectures to their education. 

O'Keeffe GW, Sullivan AM, McCarthy MM.

J Undergrad Neurosci Educ. 2017 Fall;16(1):A28-A33

PMID: 29371838

Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling.

Togher KL, Treacy E, O'Keeffe GW#, Kenny LC#. 

Psychiatry Res. 2017 Sep;255:17-26. doi: 10.1016/j.psychres.2017.05.013.   

PMID: 28511050

Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation.

Hegarty SV, Wyatt SL, Howard L, Stappers E, Huylebroeck D, Sullivan AM, O’Keeffe GW.

Sci Rep. 2017 Aug 17;7(1):8568. doi: 10.1038/s41598-017-08900-3. 

PMID: 28819210

Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation.

Straley ME, Van Oeffelen W, Theze S, Sullivan AM, O'Mahony SM, Cryan JF, O'Keeffe GW.

Brain Behav Immun. 2017 Jul;63:21-34. doi: 10.1016/j.bbi.2016.06.002. 

PMID: 27266391

Romidepsin induces caspase-dependent cell death in human neuroblastoma cells.

Hegarty SV, Togher KL, O'Leary E, Solger F, Sullivan AM, O'Keeffe GW.

Neurosci Lett. 2017 Jul 13;653:12-18. doi: 10.1016/j.neulet.2017.05.025. 

PMID: 28506690

A new role for placental IL-6 signalling in determining neurodevelopmental outcome.

O'Keeffe GW.

Brain Behav Immun. 2017 May;62:9-10. doi: 10.1016/j.bbi.2017.02.011. Epub 2017 Feb 17. 

PMID: 28216086

Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.

Hegarty SV, Lee DJ, O'Keeffe GW, Sullivan AM.

Parkinsonism Relat Disord. 2017 May;38:19-25. doi: 10.1016/j.parkreldis.2017.02.011. Epub 2017 Feb 10. Review.

PMID: 28215730

A practical description and student perspective of the integration of radiology into lower limb musculoskeletal anatomy.

Davy S, O'Keeffe GW, Mahony N, Phelan N, Barry DS.

Ir J Med Sci. 2017 May;186(2):409-417. doi: 10.1007/s11845-016-1487-6.

PMID: 27473576

Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Neurosci Lett. 2017 Mar 16;643:32-37. doi: 10.1016/j.neulet.2017.02.013.

PMID: 28188849

Googling in anatomy education: Can google trends inform educators of national online search patterns of anatomical syllabi?

Phelan N, Davy S, O'Keeffe GW, Barry DS.

Anat Sci Educ. 2017 Mar;10(2):152-159. doi: 10.1002/ase.1641.

PMID: 27547967

Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease.

O'Keeffe GW, Hegarty SV, Sullivan AM

Neuronal Signaling. 2017 Feb 24. doi: 10.1042/NS20170027

PMID: in process

Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells.

Togher KL, Kenny LC, O'Keeffe GW.

Int J Cell Biol. 2017;2017:6169310. doi: 10.1155/2017/6169310.

PMID: 28321257​

2016

Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism.

Collins LM, Dal Bo G, Calcagno M, Monzón-Sandoval J, Sullivan AM, Gutierrez H, Morari M, O'Keeffe GW. 

Mol Neurobiol. 2016 Dec;53(10):7284-7297.

PMID: 26687234

The Epigenome as a therapeutic target for Parkinson's disease.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Neural Regen Res. 2016 Nov;11(11):1735-1738. doi: 10.4103/1673-5374.194803. Review.

PMID: 28123403

Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta.

Williamson RD, McCarthy C, Kenny LC, O'Keeffe GW.

Pregnancy Hypertens. 2016 Oct;6(4):356-360. doi: 10.1016/j.preghy.2016.08.237.

PMID: 27939482

The need for ethical and pedagogical frameworks for developing online media in anatomy education.

Barry DS, Tierney P, O'Keeffe GW.

Anat Sci Educ. 2016 Oct;9(5):498-9. doi: 10.1002/ase.1628. No abstract available. 

PMID: 27273916

A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease.

Hegarty SV, O'Leary E, Solger F, Stanicka J, Sullivan AM, O'Keeffe GW.

Neurotox Res. 2016 Oct;30(3):510-20. doi: 10.1007/s12640-016-9636-2.

PMID: 27256286

Neurotrophic factor therapy for Parkinson's disease: past, present and future.

Sullivan AM, O'Keeffe GW.

Neural Regen Res. 2016 Feb;11(2):205-7. doi: 10.4103/1673-5374.177710. 

PMID: 27073356

Protocol for evaluation of neurotrophic strategies in Parkinson’s disease-related dopaminergic and sympathetic neurons in vitro.

Hegarty SV, Sullivan AM, O'Keeffe GW.

J. Biol. Methods 2016 July; 3(3); e50.  doi: 10.14440/jbm.2016.124 

PMID: 31453215

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms.

Felice VD, Quigley EM, Sullivan AM, O'Keeffe GW, O'Mahony SM.

Parkinsonism Relat Disord. 2016 Jun;27:1-8. doi: 10.1016/j.parkreldis.2016.03.012..

PMID: 27013171

Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation.

O'Keeffe GW, Gutierrez H, Howard L, Laurie CW, Osorio C, Gavaldà N, Wyatt SL, Davies AM.

Neural Dev. 2016 Feb 15;11:4. doi: 10.1186/s13064-016-0060-3.

PMID: 26878848

Cadaveric anatomy in the future of medical education: What is the surgeons view?

Sheikh AH, Barry DS, Gutierrez H, Cryan JF, O'Keeffe GW.

Anat Sci Educ. 2016 Mar-Apr;9(2):203-8. doi: 10.1002/ase.1560.

PMID: 26213365

Anatomy education for the YouTube generation.

Barry DS, Marzouk F, Chulak-Oglu K, Bennett D, Tierney P, O'Keeffe GW.

Anat Sci Educ. 2016 Jan-Feb;9(1):90-6. doi: 10.1002/ase.1550.

PMID: 26061143

2015

Zeb2: A multifunctional regulator of nervous system development.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Prog Neurobiol. 2015 Sep;132:81-95. doi: 10.1016/j.pneurobio.2015.07.001.

PMID: 26193487

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.

Ning Z, McLellan AS, Ball M, Wynne F, O'Neill C, Mills W, Quinn JP, Kleinjan DA, Anney RJ, Carmody RJ, O'Keeffe G, Moore T.

Hum Mol Genet. 2015 Sep 15;24(18):5126-41. doi: 10.1093/hmg/ddv231. 

PMID: 26089202

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood.

Golubeva AV, Crampton S, Desbonnet L, Edge D, O'Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O'Halloran KD, Dinan TG, O'Keeffe GW*, Cryan JF*.

Psychoneuroendocrinology. 2015 Oct;60:58-74. doi: 10.1016/j.psyneuen.2015.06.002.

PMID: 26135201

 

Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system.

Monzón-Sandoval J, Castillo-Morales A, Crampton S, McKelvey L, Nolan A, O'Keeffe G, Gutierrez H.

Front Cell Neurosci. 2015 Aug 28;9:337. doi: 10.3389/fncel.2015.00337.

PMID: 26379506

Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy.

Looney AM, Walsh BH, Moloney G, Grenham S, Fagan A, O'Keeffe GW, Clarke G, Cryan JF, Dinan TG, Boylan GB, Murray DM.

J Pediatr. 2015 Aug;167(2):269-73.e2. doi: 10.1016/j.jpeds.2015.04.060.

PMID: 26001314

Viral vector delivery of neurotrophic factors for Parkinson's disease therapy.

Kelly MJ, O'Keeffe GW, Sullivan AM.

Expert Rev Mol Med. 2015 May 13;17:e8. doi: 10.1017/erm.2015.6.

PMID: 25997719

Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker.

Williamson RD, O'Keeffe GW, Kenny LC.

Cytokine. 2015 Feb;71(2):360-5. doi: 10.1016/j.cyto.2014.11.017.

PMID: 25510903

Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult.

Collins LM, Adriaanse LJ, Theratile SD, Hegarty SV, Sullivan AM, O'Keeffe GW.

Mol Neurobiol. 2015;51(3):1432-42. doi: 10.1007/s12035-014-8820-8.

PMID: 25065734

Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease.

Walsh S, Gavin A, Wyatt S, O'Connor C, Keeshan K, Nolan YM, O'Keeffe GW, Sullivan AM.

Int J Neurosci. 2015 Jan;125(1):70-7. doi: 10.3109/00207454.2014.904304.

PMID: 24628580

2014

The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age.

Nolan AM, Collins LM, Wyatt SL, Gutierrez H, O'Keeffe GW.

Differentiation. 2014 Nov-Dec;88(4-5):124-30. doi: 10.1016/j.diff.2014.12.006.

PMID: 25582843

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.

Hegarty SV, O'Keeffe GW*, Sullivan AM*.

Neural Regen Res. 2014 Oct 1;9(19):1708-11. doi: 10.4103/1673-5374.143410. Review.

PMID: 25422631

LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation.

Straley ME, Togher KL, Nolan AM, Kenny LC, O'Keeffe GW.

Placenta. 2014 Aug;35(8):533-8. doi: 10.1016/j.placenta.2014.06.001.

PMID: 24961461

Microbiota and neurodevelopmental windows: implications for brain disorders.

Borre YE, O'Keeffe GW, Clarke G, Stanton C, Dinan TG, Cryan JF.

Trends Mol Med. 2014 Sep;20(9):509-18. doi: 10.1016/j.molmed.2014.05.002. Review.

PMID: 24956966

Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease.

Collins LM, Gavin AM, Walsh S, Sullivan AM, Wyatt SL, O'Keeffe GW, Nolan YM, Toulouse A.

Springerplus. 2014 Apr 28;3:205. doi: 10.1186/2193-1801-3-205.

PMID: 24826373

Predicting infant neurodevelopmental outcomes using the placenta?

O'Keeffe GW, Kenny LC.

Trends Mol Med. 2014 Jun;20(6):303-5. doi: 10.1016/j.molmed.2014.04.005.

PMID: 24794011

Epigenetic regulation of the placental HSD11B2 barrier and its role as a critical regulator of fetal development.

Togher KL, O'Keeffe MM, Khashan AS, Gutierrez H, Kenny LC, O'Keeffe GW.

Epigenetics. 2014 Jun;9(6):816-22. doi: 10.4161/epi.28703. Review.

PMID: 24717516

Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons.

Hegarty SV, Collins LM, Gavin AM, Roche SL, Wyatt SL, Sullivan AM, O'Keeffe GW.

Neuromolecular Med. 2014 Jun;16(2):473-89. doi: 10.1007/s12017-014-8299-5.

PMID: 24682653

Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Mol Neurobiol. 2014 Oct;50(2):559-73. doi: 10.1007/s12035-014-8639-3. Review.

PMID: 24504901

6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo.

Gavin AM, Walsh S, Wyatt S, O'Keeffe GW, Sullivan AM.

Neurosci Lett. 2014 Feb 21;561:176-81. doi: 10.1016/j.neulet.2013.12.046.

PMID: 24373993

Ventral midbrain neural stem cells have delayed neurogenic potential in vitro.

Hegarty SV, Spitere K, Sullivan AM, O'Keeffe GW.

Neurosci Lett. 2014 Jan 24;559:193-8. doi: 10.1016/j.neulet.2013.12.009.

PMID: 24342440

2013

BMP-Smad 1/5/8 signalling in the development of the nervous system.

Hegarty SV, O'Keeffe GW, Sullivan AM.

Prog Neurobiol. 2013 Oct;109:28-41. doi: 10.1016/j.pneurobio.2013.07.002. Review.

PMID: 23891815

BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Mol Cell Neurosci. 2013 Sep;56:263-71. doi: 10.1016/j.mcn.2013.06.006.

PMID: 23831389

Peroxisomes: the neuropathological consequences of peroxisomal dysfunction in the developing brain.

Barry DS, O'Keeffe GW.

Int J Biochem Cell Biol. 2013 Sep;45(9):2012-5. doi: 10.1016/j.biocel.2013.06.019.

PMID: 23830890

NF-κB: emerging roles in hippocampal development and function.

Crampton SJ, O'Keeffe GW.

Int J Biochem Cell Biol. 2013 Aug;45(8):1821-4. doi: 10.1016/j.biocel.2013.05.037.

PMID: 23764620

Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.

Hegarty SV, Sullivan AM, O'Keeffe GW.

Dev Biol. 2013 Jul 15;379(2):123-38. doi: 10.1016/j.ydbio.2013.04.014.

PMID: 23603197

Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons.

Collins LM, O'Keeffe GW, Long-Smith CM, Wyatt SL, Sullivan AM, Toulouse A, Nolan YM.

Neuromolecular Med. 2013 Jun;15(2):435-46. doi: 10.1007/s12017-013-8230-5.

PMID: 23584919

Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.

Ryan SM, O'Keeffe GW, O'Connor C, Keeshan K, Nolan YM.

Brain Behav Immun. 2013 Oct;33:7-13. doi: 10.1016/j.bbi.2013.03.005.

PMID: 23510989

Regulation of neurite growth by tumour necrosis superfamily member RANKL.

Gutierrez H, Kisiswa L, O'Keeffe GW, Smithen MJ, Wyatt S, Davies AM.

Open Biol. 2013 Jan 8;3(1):120150. doi: 10.1098/rsob.120150.

PMID: 23303310

2012

The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling.

McKelvey L, Gutierrez H, Nocentini G, Crampton SJ, Davies AM, Riccardi CR, O'keeffe GW.

Biol Open. 2012 Oct 15;1(10):1016-23. doi: 10.1242/bio.20121024. Epub 2012 Aug 20.

PMID: 23213379

Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease.

Costello DJ, O'Keeffe GW, Hurley FM, Sullivan AM.

J Cell Mol Med. 2012 Oct;16(10):2451-60. doi: 10.1111/j.1582-4934.2012.01562.x.

PMID: 22436046

A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells.

Green HF, Treacy E, Keohane AK, Sullivan AM, O'Keeffe GW, Nolan YM.

Mol Cell Neurosci. 2012 Mar;49(3):311-21. doi: 10.1016/j.mcn.2012.01.001. Epub 2012 Jan 16.

PMID: 22270046

Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?

Crampton SJ, Collins LM, Toulouse A, Nolan YM, O'Keeffe GW.

J Neurochem. 2012 Mar;120(6):964-73. doi: 10.1111/j.1471-4159.2011.07634.x. Epub 2012 Feb 9.

PMID: 22192001

To 2011

IL-1β inhibits axonal growth of developing sympathetic neurons.

Nolan AM, Nolan YM, O'Keeffe GW.

Mol Cell Neurosci. 2011 Oct;48(2):142-50. doi: 10.1016/j.mcn.2011.07.003. Epub 2011 Jul 21.

PMID: 21791245

Nuclear factor kappa B signaling either stimulates or inhibits neurite growth depending on the phosphorylation status of p65/RelA.

Gutierrez H, O'Keeffe GW, Gavaldà N, Gallagher D, Davies AM.

J Neurosci. 2008 Aug 13;28(33):8246-56. doi: 10.1523/JNEUROSCI.1941-08.2008.

PMID: 18701687

Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor.

Vizard TN, O'Keeffe GW, Gutierrez H, Kos CH, Riccardi D, Davies AM.

Nat Neurosci. 2008 Mar;11(3):285-91. doi: 10.1038/nn2044. Epub 2008 Jan 27.

PMID: 18223649

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease.

O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell MA.

Brain. 2008 Mar;131(Pt 3):630-41. doi: 10.1093/brain/awm340. Epub 2008 Jan 17.

PMID: 18202103

NGF-promoted axon growth and target innervation requires GITRL-GITR signaling.

O'Keeffe GW, Gutierrez H, Pandolfi PP, Riccardi C, Davies AM.

Nat Neurosci. 2008 Feb;11(2):135-42. doi: 10.1038/nn2034. Epub 2008 Jan 6.

PMID: 18176559

Nuclear factor-kappaB activation via tyrosine phosphorylation of inhibitor kappaB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons.

Gallagher D, Gutierrez H, Gavalda N, O'Keeffe G, Hay R, Davies AM.

J Neurosci. 2007 Sep 5;27(36):9664-9.

PMID: 17804627

Donor age affects differentiation of rat ventral mesencephalic stem cells.

O' Keeffe GW, Sullivan AM.

Neurosci Lett. 2005 Feb 28;375(2):101-6. Epub 2004 Nov 30.

PMID: 15670650

The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment.

Sullivan AM, O'Keeffe GW.

J Anat. 2005 Sep;207(3):219-26. Review.

PMID: 16185246

Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro.

O'Keeffe GW, Dockery P, Sullivan AM.

J Neurocytol. 2004 Sep;33(5):479-88.

PMID: 15906156

Expression of growth differentiation factor-5 in the developing and adult rat brain.

O'Keeffe GW, Hanke M, Pohl J, Sullivan AM.

Brain Res Dev Brain Res. 2004 Jul 19;151(1-2):199-202.

PMID: 15246706

O'Keeffe lab, University,

College Cork, Cork, Ireland

© 2018 O'Keeffe lab

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